abstract：:The innate immune system is the first line of defense against invading pathogens and is particularly important in warding off bacterial and viral infections presenting at the mucosal cell surface. From this primitive immune response, the more sophisticated adaptive immune system was derived. Despite nearly two decades...

journal_title：Trends in immunology

authors： Levy JA

更新日期：2001-06-01 00:00:00

abstract：:Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independen...

journal_title：Trends in immunology

authors： Fiorucci S

更新日期：2001-05-01 00:00:00

abstract：:Oral tolerance is a well-characterized phenomenon in animals and is highly effective when induced as a treatment for experimental autoimmune disease. However, its use as a therapeutic modality for the treatment of autoimmune disease in humans has been disappointing. Much of the rationale for its use in humans is based...

journal_title：Trends in immunology

authors： MacDonald TT,Monteleone G

更新日期：2001-05-01 00:00:00

abstract：:Specific immunotherapy (SIT) is a common treatment for allergic diseases. Despite its usage in clinical practice for nearly a century, more-rational and safer allergen preparations are required. Here, the underlying mechanisms and principles of allergen modification for the future use of SIT in the treatment of allerg...

journal_title：Trends in immunology

authors： Akdis CA,Blaser K

更新日期：2001-04-01 00:00:00

abstract：:Immuno-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several autoimmune diseases an...

journal_title：Trends in immunology

authors： Prud'homme GJ,Lawson BR,Chang Y,Theofilopoulos AN

更新日期：2001-03-01 00:00:00

abstract：:Although therapy-mediated suppression of HIV-1 is effective and results in a degree of immune reconstitution, the complications resulting from life-long treatment emphasize the need for alternatives. This review discusses the use of structured interruptions in antiviral therapy to induce drug-free periods of immune-me...

journal_title：Trends in immunology

authors： Montaner LJ

更新日期：2001-02-01 00:00:00

abstract：:Genomic-scale gene expression profiling can reveal cellular physiology with unprecedented richness. This technology is being used to define the gene expression targets of individual regulatory proteins and signaling pathways. Comprehensive databases of gene expression measurements can be used to understand the patholo...

journal_title：Trends in immunology

authors： Staudt LM

更新日期：2001-01-01 00:00:00